Salling Clicker + Smart Phone/PDA 
If you have a smart phone or Wi-Fi/Bluetooth enabled PDA then the ultimate remote control is the Salling Clicker software, made by Salling Software in Sweden. It really is brilliant software, and works like a charm. With the software installed on the PC and also on the handheld, you can control iTunes directly with a very similar UI to an iPod. In fact, I would go so far as to say it is better than an iPod, because it takes full advantage of the touchscreen and navigation buttons on the device. Hundreds of different smartphones and PDA models are supported.
Of course, this is a much more expensive remote solution than the ATI Remote Wonder since you need to have a smartphone or a PDA but the experience you get with this combined with the Sirocco approaches what I think is the ideal home audio set up:
1. Access to all content, both stored locally and live from the net.
2. A graphical and intuitive UI that runs on a device that doesn't have to be powered all the time. You just turn on the PDA when you want to change something.
3. Audiophile-grade quality and 100% format/DRM compatibility via the C-Media Wi-Sonic technology in the Sirocco.